Patient on HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase]

Frequently Asked Questions About HYQVIA

These questions and answers can help you learn important information about HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase].

For specific questions about how HYQVIA may work for you, please consult with your physician.

Download the complete list of HYQVIA frequently asked questions.

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Prescribing Information

About HYQVIA

Q: What is HYQVIA?
A: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is a liquid medicine containing Recombinant Human Hyaluronidase and immune globulin (Ig) and is used to treat adult patients with primary immunodeficiency (PI) diseases.1

HYQVIA is infused under the skin into the fatty subcutaneous, or subQ, tissue. With HYQVIA you have the option to infuse using 1 needle, 1 infusion site,1 time a month, in the comfort of your own home or in a healthcare facility (doctor's office or infusion center). Your doctor may consider the use of a second infusion site based on the total volume to be infused and how well you tolerate your infusions.1 More about HYQVIA.
Q: Why am I being prescribed HYQVIA?
A: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is used to treat adults with PI. Just 1 subQ infusion a month can help your body fight off bacterial and viral infections. As demonstrated in the clinical trial, the rate of acute serious bacterial infections was 0.025 per patient per year, and there were 0 days spent in the hospital due to infection.1 More about HYQVIA.
Q: How does HYQVIA work?
A: The Immune Globulin Infusion 10% (Human), or Ig, part of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] contains IgG antibodies collected from human plasma donated by healthy people. The antibodies help your body to fight off bacterial and viral infections. The Recombinant Human Hyaluronidase part of HYQVIA helps more of the infused Ig get absorbed into the body to fight infection.1 See how HYQVIA works.
Q: What is Recombinant Human Hyaluronidase?
A: Recombinant Human Hyaluronidase enhances the flow of Ig into the subQ tissue and into the bloodstream.1 See how HYQVIA works.
Q: Is Recombinant Human Hyaluronidase used in the treatment of other things?
A: Hyaluronidase was approved in 2005 under the brand name HYLENEX as an adjuvant (an aide in treatment).3
  • In subcutaneous fluid administration for achieving hydration
  • To increase the dispersion and absorption of other injected drugs
  • In subcutaneous urography (method for examining urinary system) for improving resorption (reabsorption) of radioopaque (unable to be seen through radiation) agents
Q: What makes HYQVIA different from other subQ Ig treatments?
A: Conventional subQ Ig treatments require multiple infusions a month, with multiple needles, to receive your monthly dose.2

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is the only once-a-month subQ Ig with Recombinant Human Hyaluronidase and Ig. The hyaluronidase temporarily opens up the subQ space, allowing a larger amount of Ig to reach the subQ tissue and be absorbed into the bloodstream to help fight infection.1

It's the reason you can infuse your monthly dose of HYQVIA using 1 needle, 1 infusion site, 1 time a month. A second site can be used at the discretion of the physician and patient based on tolerability and total volume.1 Learn more about how HYQVIA works.

Infusing HYQVIA

Q: How can HYQVIA be administered?
A: You can self-administer HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] after receiving the appropriate training, or a caregiver can administer HYQVIA in your home after receiving appropriate training. Do not use HYQVIA at home until you get instructions and training from your healthcare professional. If you would feel more comfortable, HYQVIA can also be administered by a healthcare professional at your doctor's office, clinic, or hospital.1 Learn more about administering HYQVIA.
Q: How often do I need to infuse HYQVIA?
A: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is infused under the skin into the fatty subcutaneous (subQ) tissue using 1 needle, 1 infusion site, 1 time a month. Your doctor may consider the use of a second infusion site based on the total volume to be infused and how well you tolerate your infusions.1 Follow your healthcare professional's instructions regarding the dose, schedule, and how to infuse, so your treatment with HYQVIA will be individualized for you. Your healthcare professional may perform blood tests from time to time after you start HYQVIA to check your serum IgG level.1 Learn more about infusing HYQVIA.
Q: How long does it take to infuse HYQVIA?
A: Infusing 1 time a month doesn't mean your infusions will take longer. Typically, HYQVIA infusions take less than 3 hours. During the clinical trial, the median duration of an individual HYQVIA infusion was 2 hours and 5 minutes after the initial ramp-up period.1 Learn more about infusing HYQVIA.
Q: How do I infuse HYQVIA?
A: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is infused under the skin into the fatty, or subQ, tissue.1
  • Infuse the two components of HYQVIA sequentially, beginning with the Recombinant Human Hyaluronidase.
  • Initiate the infusion of the full dose of the Immune Globulin Infusion 10% (Human) through the same subcutaneous needle set within approximately 10 minutes of the Recombinant Human Hyaluronidase infusion.

HYQVIA can be self-administered at home after receiving the appropriate training or at your doctor's office, clinic, or hospital by a healthcare professional. If you and your doctor decide that self-administration is right for you, a healthcare professional will train you on how to infuse HYQVIA at home and make sure you're comfortable doing it on your own. Do not use HYQVIA at home until you get instructions and training from your healthcare professional. See how to infuse HYQVIA.
Q: What does HYQVIA look like?
A: The Recombinant Human Hyaluronidase component should be clear and colorless. The Ig component should be clear and colorless or pale yellow.1
Q: Which vial do I infuse first?
A: The 2 components of HYQVIA are infused sequentially through the same subcutaneous needle set. The Recombinant Human Hyaluronidase is infused first by manually hand pushing it. The IG of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is administered within approximately 10 minutes of the Recombinant Human Hyaluronidase using a variable rate infusion pump at a rate recommended by your physician or infusion provider.1 Watch how to infuse HYQVIA.
Q: What supplies will I need for infusing at home?
A: When you infuse at home, you will need the HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] dual vials, ancillary supplies for infusions, 24 gauge needle set labeled for high flow rates, a sharps container, an infusion log, and an infusion pump. The infusion pump should be programmed according to your healthcare professional's recommendation and the manufacturer's instructions.1 Watch a short administration video.
Q: What infusion sites should I use?
A: The suggested sites for the infusion of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] are the middle to upper abdomen and thighs. If 2 sites are used, the 2 infusion sites should be on opposite sides of the body. Avoid bony prominences, or areas that are scarred, inflamed, or infected. HYQVIA should not be infused into or around an infected or red swollen area because it could cause an infection to spread.1 Learn more about infusing HYQVIA.
Q: How should I store HYQVIA at home?
A: Protect HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] from light by keeping the vials in their original boxes.1

Do not freeze HYQVIA. It can be stored in a refrigerator (36°F to 46°F [2°C to 8°C]) for up to 36 months from the date of manufacture. Check the box and vial label for the date of expiration.1

You can store HYQVIA at room temperature up to 77°F (25°C) for up to 3 months within 24 months. HYQVIA must be used within 3 months after removal to room temperature but within the expiration date on the outer carton and vial label.1

After you remove HYQVIA from the refrigerator and store it at room temperature, do not refrigerate it again.1

Always check the expiration date printed on the box and vial label. You should not use HYQVIA after the expiration date.1 For more information, read the Full Prescribing Information.
Q: Do I use the same pump as I did for other Ig treatments?
A: Infusion of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] requires an infusion pump capable of infusing full therapeutic dose at infusion rates up to 300 mL/hr/site. The pump must have the ability to titrate the flow rate up or down if required to improve tolerability.1 Watch how to infuse HYQVIA.
Q: How will my skin feel and look after my HYQVIA infusions?
A: After infusing with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], a temporary soft swelling, which may last 1-3 days, can occur due to the volume of fluid infused.

Mild-to-moderate pain, itching, swelling, and redness at the infusion site are common local infusion-site reactions, but they usually go away within a few hours. Local infusion-site reactions are less likely to occur after the first few infusions.1

More than 98% of infusion-site reactions were mild to moderate.1

Learn more about what to expect with HYQVIA.
Q: Will HYQVIA affect my skin long term?
A: In the clinical trials, there were no observable changes in the skin or subcutaneous tissue in almost 3000 infusions and maximum exposure of over 3 years (2959 infusions and 188 subject-years).1 Learn more about what to expect with HYQVIA.
Q: Is there a numbing cream or something I can put on my skin to make infusing more comfortable?
A: Some patients use EMLA Cream, which contains 2 local anesthetics called lidocaine and prilocaine.4 EMLA Cream works by temporarily numbing the surface of the skin to prevent pain on the skin. However, it's normal to still feel pressure on touch.

Talk to your healthcare professional if you'd like to have him or her prescribe a topical anesthetic.
Q: What if I have trouble infusing HYQVIA?
A: Your healthcare professional will train you on how to self-infuse HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] at home and make sure you're comfortable doing it on your own. Talk to your healthcare professional immediately if you have trouble infusing HYQVIA. The frequency and number of infusion sites of HYQVIA can be adjusted by your healthcare professional, taking into consideration volume, total infusion time, tolerability, and clinical response.1 Get support for managing your treatment.

Infusion Schedule and Dosing

Q: What will my infusion schedule be like when I start HYQVIA?
A: To help you become comfortable with your treatment, you will receive the first dose of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] and will ramp up gradually.1 Your dose will eventually shift from 1 time a week to 1 time a month (every 3 to 4 weeks).1

If you were previously on another Ig treatment, you will receive your first dose of HYQVIA approximately 1 week after your last infusion.1

Everyone taking HYQVIA will start with the ramp-up period, regardless of whether you are new to SubQ Ig treatment or just new to HYQVIA. Your HYQVIA dose and infusion frequency may need to be adjusted based on your clinical response.1 Learn more about the ramp-up period.
Q: Why do I need to ramp-up my dose?
A: The initial ramp-up period allows you to become familiar with the large volumes required for a subQ infusion of a full 3- to 4-week dose of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase]. You will receive your first dose of HYQVIA and gradually increase the dose and decrease the frequency from once a week to once every 3 to 4 weeks. Learn more about the ramp-up period.
Q: How much will I need to infuse after the ramp-up?
A: Follow your healthcare professional's instructions regarding the dose, schedule, and how to infuse, so that your treatment with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] will be individualized for you. Your healthcare professional may perform blood tests from time to time after you start HYQVIA to check your IgG level.
Q: I'm on intravenous Ig treatment now. Will my infusion schedule change with HYQVIA?
A: For most people who switch from intravenous Ig (IVIG) infusion, HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] will be administered at the same dose and frequency as IVIG (after the ramp-up period). However, if HYQVIA is administered at a different interval than your previous treatment, your doctor may need to adjust the dose of HYQVIA based on your clinical response.1 For more information, see the Full Prescribing Information.
Q: I'm on a different SubQ Ig treatment now. Will my infusion schedule change with HYQVIA?
A: For most people who switch from a different subQ Ig, HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] will be administered at 300 to 600 mg/kg at 3- to 4-week intervals, after initial ramp-up. However, your healthcare professional may need to adjust the dose and frequency of HYQVIA based on your clinical response.1 For more information, see the Full Prescribing Information.
Q: Does HYQVIA offer steady-state immune globulin (Ig) levels?
A: The peak-to-trough variation is more similar to conventional subcutaneous administration, even with once-a-month administration (every 3 to 4 weeks). Also, HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] does not have the high peak Ig level experienced with intravenous administration.1 Learn more about what HYQVIA can provide.

HYQVIA Support

Q: Does HYQVIA cost more than other Ig treatments?
A: Your costs for HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] will depend on many factors, including your pharmacy provider and your insurance plan. To help support patients, Shire has created the MyIgCoPayCard Program for eligible patients with commercial insurance. Learn more about the MyIgCoPayCard Program, including eligibility.
Q: Will my insurance cover HYQVIA?
A: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] is covered similarly to other treatments of PI, but coverage may vary by plan. If you need help navigating your insurance plan or understanding your coverage, talk to your infusion provider, call 1-855-250-5111, or visit MyIgSource.com to learn more.
Q: What if I need help paying for HYQVIA?
A: If you are an adult PI patient on a prescribed Shire Ig treatment with commercial insurance you may be able to save up to $5,000 within a 12-month period on your out of pocket co-payment, co-insurance, or deductible for medication costs with MyIgCoPayCard. Terms and conditions apply. Learn more about the MyIgCoPayCard Program, including eligibility requirements.
Q: What if I have a medical question or experience side effects?
A: If you have a medical question regarding the use of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], or if you experience side effects, please contact your healthcare provider.
Q: Where can I turn if I have general questions or need support?
A: MyIgSource is a free support program for people living with or caring for someone with primary immunodeficiency (PI). With MyIgSource, you'll receive insurance and financial support, emotional support from Patient Advocates, HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] support from a Nurse Advocate, plus educational tools and resources to help you manage PI. Reach out for support today. Call 1-855-250-5111 or visit MyIgSource.com to enroll in the program.

Additional Questions About HYQVIA

Q: When was HYQVIA approved in the US?
A: On September 12, 2014 the FDA approved HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] for the treatment of adult patients with PI.
Q: How long has HYQVIA been approved in Europe?
A: It was approved for use in the EU in May 2013.5
Q: Why is HYQVIA only approved for adults?
A: Safety has not been established in children.1
Q: Has Recombinant Human Hyaluronidase been used chronically in other conditions?
A: Safety and efficacy of chronic use of Recombinant Human Hyaluronidase of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] has not been established in conditions other than PI.1
Q: Can pregnant women take HYQVIA?
A: Studies in pregnant women have not been conducted with HYQVIA. No human data are available to indicate the presence or absence of drug-associated risk. Immune globulins cross the placenta from maternal circulation increasingly after 30 weeks of gestation. HYQVIA should be given to a pregnant woman only if clearly indicated. Talk to your doctor if you become pregnant while on HYQVIA. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling 1-866-424-67241.
Q: Can taking HYQVIA affect fertility?
A: Long-term studies on fertility have not been conducted with the Immune Globulin Infusion 10% (Human) component of HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase]. It is not known whether HYQVIA can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.1

Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any effect on human fertility. In theory, these antibodies could react with your body's own hyaluronidase. Hyaluronidase is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects.1

Safety Considerations

Q: What are the serious side effects that can be caused by HYQVIA?
A: Call your healthcare professional or go to your emergency department right away if you get:
  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling in your brain.
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
  • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a lung problem.

These are not all the possible side effects with HYQVIA. Talk to your healthcare professional about any side effects that bother you or that don't go away.

Please see FDA-approved patient labeling and discuss with your doctor.
Q: What is the most important safety information I should know about HYQVIA?
A:
  • HYQVIA can cause blood clots.
  • Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
  • Your healthcare professional may perform blood tests regularly to check your IgG level.
  • With your consent, your healthcare professional may provide blood samples to Shire plc, to test for antibodies that may form against the hyaluronidase part of HYQVIA.
  • Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.
  • Talk to your healthcare professional if you become pregnant. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling 1-866-424-6724.

Please see FDA-approved patient labeling and discuss with your doctor.
Q: What are the possible or reasonably likely side effects of HYQVIA?
A: After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. Mild or moderate pain, redness, swelling, or itching may occur at the site of infusion and generally go away in a few hours. Local reactions are less likely after the first few infusions. The most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.

Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long term effect. In theory, these antibodies could react with your body's own PH20. PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects.

Please see FDA-approved patient labeling and discuss with your doctor.
Q: What do I need to tell my doctor before starting HYQVIA?
A: Before starting HYQVIA, tell your healthcare professional if you have or had any kidney, liver, or heart problems, a history of blood clots, because HYQVIA can make these problems worse. Also tell your doctor if you have IgA deficiency or a history of severe allergic reactions to immune globulin (IgG) or other blood products, or are pregnant, trying to become pregnant or are breast feeding.

Please see FDA-approved patient labeling and discuss with your doctor.
Q: Who should not take HYQVIA?
A: Do not take HYQVIA if you are allergic to IgG, hyaluronidase, or other blood products, or have IgA deficiency with antibodies to IgA.

Please see FDA-approved patient labeling and discuss with your doctor.

Please expand for Indication and Important Safety Information.

Selected Important Safety Information about HYQVIA
  • HYQVIA can cause blood clots. Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
  • Do not take HYQVIA if you are allergic to IgG, hyaluronidase, other blood products, human albumin (in the hyaluronidase solution), or have IgA deficiency with antibodies to IgA.
Indication and Important Safety Information
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] Solution
  • HYQVIA is a liquid medicine containing immune globulin and Recombinant Human Hyaluronidase. HYQVIA contains IgG antibodies, collected from human plasma donated by healthy people. The antibodies help your body to fight off bacterial and viral infections. The hyaluronidase part of HYQVIA helps more of the immune globulin get absorbed into the body to fight infection.
  • HYQVIA is indicated for the treatment of Primary Immunodeficiency (PI) involving the humoral immune system in adults.
  • Safety and efficacy of chronic use of Recombinant Human Hyaluronidase in HYQVIA have not been established in conditions other than PI.
  • HYQVIA is infused under the skin (subcutaneous).
  • If you and your healthcare professional decide that home self-infusion of HYQVIA is right for you, then be sure you get instructions and training from your healthcare professional before using HYQVIA at home.
Important Safety Information
    • HYQVIA can cause blood clots.
    • Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
    • Your healthcare professional may perform blood tests regularly to check your IgG level.
    • With your consent, your healthcare professional may provide blood samples to Shire plc, to test for antibodies that may form against the hyaluronidase part of HYQVIA.
    • Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.
    • Talk to your healthcare professional if you become pregnant. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling Medical Information at 1-866-424-6724.

    Do not take HYQVIA if you:

    • Are allergic to IgG, hyaluronidase, other blood products, or human albumin (in the hyaluronidase solution).
    • Have IgA deficiency with antibodies to IgA.

    HYQVIA can cause serious side effects. Call your healthcare professional or go to your emergency department right away if you get:

    • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
    • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling in your brain.
    • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
    • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
    • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
    • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a lung problem.

    What are the possible or reasonably likely side effects of HYQVIA?

    • After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. Mild or moderate pain, redness, swelling, or itching may occur at the site of infusion and generally go away in a few hours. Local reactions are less likely after the first few infusions.
    • The most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.
    • Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long term effect. In theory, these antibodies could react with your body’s own PH20. PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects.

    These are not all the possible side effects with HYQVIA. Talk to your healthcare professional about any side effects that bother you or that don’t go away.

    Before starting HYQVIA, tell your healthcare professional if you:

    • Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
    • Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
    • Are pregnant, trying to become pregnant or are breast feeding.

    You are encouraged to report suspected side effects by contacting FDA at 1-800-FDA-1088 or www.fda.gov/medwatch or Shire Drug Safety at 1-800-999-1785.

    The risk information provided here is not comprehensive. To learn more, talk about HYQVIA with your healthcare provider or pharmacist.

    Please see the FDA-approved patient labeling