The Ramp-Up Period1
To help you become comfortable with your treatment, after you receive the first dose of HYQVIA you will ramp up gradually. Your dose will eventually shift from 1 time a week to 1 time a month. Here is a typical schedule for a 4 week maintenance treatment schedule for starting HYQVIA.
Dose adjustment of HYQVIA may be necessary based on your clinical response.Download Ramp-Up Schedule (PDF)
After the Ramp-Up: Once a Month!*
Once the ramp-up period has been completed, your treatment schedule is one infusion, one time a month. A second site can be used at the discretion of the physician and patient based on tolerability and total volume.
Dose adjustment of HYQVIA may be necessary based on your clinical response.*Every 3-4 weeks
What It Looks Like When You Infuse With HYQVIA1
Following your infusion with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], it's not uncommon to experience a temporary, soft swelling at the infusion site. This is due to the volume of fluid infused and may last 1 to 3 days after your infusion.
Local infusion-site reactions such as mild or moderate pain, swelling, redness, and itching may also occur and generally go away within a few hours. Local reactions are less likely to occur after the first few infusions.
In the clinical trials there were no observable changes in the skin or subcutaneous tissue in almost 3000 infusions and maximum exposure of over 3 years.†
HYQVIA infused: 494 mL*
*Volume infused as per the doctor's guidance based on this patient's specific clinical condition; it may be different for you.
†2959 infusions and 188 subject-years.
What are the possible or reasonably likely side effects of HYQVIA?
After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. Mild or moderate pain, redness, swelling, or itching may occur at the site of infusion and generally go away in a few hours. Local reactions are less likely after the first few infusions. The most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.
Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long-term effect. In theory, these antibodies could react with your body's own PH20. PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects.