The Ramp-Up Period1
After you receive the first dose of HYQVIA, you will ramp up gradually. Your dose will eventually shift from 1 time a week to 1 time every 3 or 4 weeks. Here is a typical schedule for a 4-week maintenance treatment schedule for starting HYQVIA.
Dose adjustment of HYQVIA may be necessary based on your clinical response.
After the Ramp-Up: Once a Month!*
Once the ramp-up period has been completed, your treatment schedule is one infusion, one time a month. A second site can be used at the discretion of the physician and patient based on tolerability and total volume.
Dose adjustment of HYQVIA may be necessary based on your clinical response.*Once-a-month means every 3 to 4 weeks.
What It Looks Like When You Infuse With HYQVIA1
Following your infusion with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], it's not uncommon to experience a temporary, soft swelling at the infusion site. This is due to the volume of fluid infused and may last 1 to 3 days after your infusion. The volume you'll infuse will be based on your doctor's guidance and your specific clinical condition; it may be different from the volumes shown here.
Local infusion-site reactions such as mild or moderate pain, swelling, redness, and itching may also occur and generally go away within a few hours. Local reactions are less likely to occur after the first few infusions.
In the clinical trials there were no observable changes in the skin or subcutaneous tissue in almost 3000 infusions and maximum exposure of over 3 years.*
HYQVIA infused: 494 mL‡
‡2959 infusions and 188 subject-years.
What to do if you experience a general (systemic) reaction
In addition to local reactions, the most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.1
Call your healthcare professional or go to your emergency department right away if you get:
- Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
- Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling and irritation of the lining around your brain
- Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
- Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
- Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
- Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
- Fever over 100°F. This could be a sign of an infection.
Talk to your healthcare professional about any side effects that bother you or that don’t go away.