What to Expect With HYQVIA

Here you'll find information on what to expect with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase]. Learn more about the HYQVIA Ramp-Up period, how to start treatment, and view real patient photos of what a HYQVIA infusion looks like.

The Ramp-Up Period1

After you receive the first dose of HYQVIA, you will ramp up gradually. Your dose will eventually shift from 1 time a week to 1 time every 3 or 4 weeks. Here is a typical schedule for a 4-week maintenance treatment schedule for starting HYQVIA.

Dose adjustment of HYQVIA may be necessary based on your clinical response.

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] infusions schedule

After the Ramp-Up: Once a Month!*

Once the ramp-up period has been completed, your treatment schedule is one infusion, one time a month. A second site can be used at the discretion of the physician and patient based on tolerability and total volume.

Dose adjustment of HYQVIA may be necessary based on your clinical response.

*Once-a-month means every 3 to 4 weeks.

What It Looks Like When You Infuse With HYQVIA1

Following your infusion with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], it's not uncommon to experience a temporary, soft swelling at the infusion site. This is due to the volume of fluid infused and may last 1 to 3 days after your infusion. The volume you'll infuse will be based on your doctor's guidance and your specific clinical condition; it may be different from the volumes shown here.

Example of soft swelling at the infusion site
Pre-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site prior to 500 mL infusion
Post-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of post-infusion swelling with 500 mL infusion
24 Hours After Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site 24 hours after 500 mL infusion

HYQVIA infused: 500 mL*

Pre-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of the infusion site prior to 225 mL infusion
Post-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of soft swelling at the infusion site with 225 mL infusion
24 Hours After Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of swelling at the infusion site after 24 hours with 225 mL infusion

HYQVIA infused: 225 mL

Local infusion-site reactions such as mild or moderate pain, swelling, redness, and itching may also occur and generally go away within a few hours. Local reactions are less likely to occur after the first few infusions.

In the clinical trials there were no observable changes in the skin or subcutaneous tissue in almost 3000 infusions and maximum exposure of over 3 years.*

Example of a mild local site reaction
Pre-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of pre-infusion
Post-Infusion
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of a mild local site reaction post infusion

HYQVIA infused: 494 mL

2959 infusions and 188 subject-years.

What to do if you experience a general (systemic) reaction

In addition to local reactions, the most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.1

Call your healthcare professional or go to your emergency department right away if you get:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling and irritation of the lining around your brain
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
  • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
  • Fever over 100°F. This could be a sign of an infection.

Talk to your healthcare professional about any side effects that bother you or that don’t go away.

Please expand for Indication and Important Safety Information.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about HYQVIA?

  • HYQVIA can cause blood clots.
  • Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.

HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat primary immunodeficiency (PI) in adults.

Important Safety Information
    • HYQVIA can cause blood clots.
    • Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
    • Your HCP may perform blood tests regularly to check your IgG level.
    • With your consent, your HCP may provide blood samples to Shire plc, to test for antibodies that may form against the hyaluronidase part of HYQVIA.
    • Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.
    • Talk to your HCP if you become pregnant. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling 1-866-424-6724.

    Do not take HYQVIA if you:

    • Are allergic to IgG, hyaluronidase, other blood products, or any ingredient in HYQVIA.
    • HYQVIA can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your HCP that you take HYQVIA.

    Before starting HYQVIA, tell your HCP if you:

    • Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
    • Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
    • Are pregnant, trying to become pregnant or are breast feeding.

    HYQVIA can cause serious side effects. If any of the following problems occur after starting HYQVIA, stop the infusion immediately and contact your HCP or call emergency services:

    • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
    • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
    • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
    • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
    • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
    • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
    • Fever over 100°F. This could be a sign of an infection.

    After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. The following possible side effects may occur at the site of infusion and generally go away within a few hours, and are less likely after the first few infusions.

    • Mild or moderate pain
    • Redness
    • Swelling
    • Itching

    The most common side effects of HYQVIA are:

    • Headache
    • Fatigue
    • Nausea
    • Fever
    • Vomiting

    These are not all the possible side effects. Talk to your HCP about any side effect that bothers you or that does not go away.

    For additional safety information, click for Information For Patients and discuss with your HCP.

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.