How to Infuse HYQVIA

Infusing HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] may be different than what you’re used to. But you’re not alone. We have many tools and resources, including Patient and Nurse Advocates, who can help you get started.

Step-by-Step Guides

In addition to the training you will receive from your healthcare team during the ramp-up period, these step-by-step guides can help you get off to a good start with your HYQVIA infusions. Select the PDF or video that applies to you.

HYQVIA can be administered using a Peristaltic Infusion pump or a Syringe driver pump. You, your healthcare professional and pharmacy will determine which equipment is right for you.

How to infuse HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] with a peristaltic infusion pump Play Video
How to Infuse HYQVIA with a Peristaltic Infusion Pump

Administering HYQVIA with a peristaltic infusion pump

How to infuse HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] with a syringe driver pump Play Video
How to Infuse HYQVIA with a Syringe Driver Pump

Administering HYQVIA with a syringe driver pump

Have an infusion question?

Keep your healthcare team’s contact information within reach while infusing. Also, you can call a nurse advocate at 1-855-250-5111 today.*

Don't forget that you can call a Nurse Advocate at 1-855-250-5111 with infusion questions.*

Don't forget that you can call a Nurse Advocate at 1-855-250-5111 with infusion questions.*

*Nurse Advocates cannot provide medical advice. For medical questions, please contact your physician.

What You Should Know About Self-Infusing With HYQVIA1

Coming Soon - Download and print out this handy reference guide (PDF)

Before the Infusion:

Follow the HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] directions from your healthcare provider

Always follow the directions provided to you by your healthcare professional regarding the dose, schedule, and how to infuse HYQVIA.

Make sure you are hydrated

Ensure you're hydrated by drinking plenty of fluids before you infuse.

Choose a less busy day and plan ahead

Choose a less busy day and plan ahead to avoid disruptions while infusing.

Set up your supplies before infusion

Set up your supplies in a clean area and carefully read the instructions provided to you.

Allow HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] to reach room temperature before infusion

Allow HYQVIA to reach room temperature (this may take up to 60 minutes).

Keep HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] in the box to avoid sunlight

HYQVIA can be held at room temperature up to 3 months during the first 24 months from date of manufacturing printed on the carton. Be sure to keep it in the box to protect it from light.

During the Infusion:

  • Get comfortable and try to relax during your infusion.
  • Local infusion-site reactions such as mild to moderate pain, temporary soft pancake-like swelling, itching, and skin redness are common with HYQVIA.
    • Flat, pancake-like swelling may last 1 to 3 days.
    • Other infusion-site reactions generally go away within a few hours.
  • In addition to local reactions, most common side effects may include headache, fatigue, nausea, fever, and vomiting.
  • If side effects increase in severity or persist for more than a few days, call your physician or hospital emergency services immediately.
  • Never infuse HYQVIA into or around an infected or red swollen area.
  • Let your doctor know if you experience any leakage at your infusion site.
Tips for staying comfortable during HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] infusion

After the Infusion:

  • Continue drinking fluids to remain hydrated.
  • Record your infusion time, date, dose, infusion-site location, and any reactions you may experience in your infusion log.
  • Make sure to follow up with your physician routinely.
Tips for after infusion

Please expand for Indication and Important Safety Information.

Selected Important Safety Information about HYQVIA
  • HYQVIA can cause blood clots. Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
  • Do not take HYQVIA if you are allergic to IgG, hyaluronidase, other blood products, human albumin (in the hyaluronidase solution), or have IgA deficiency with antibodies to IgA.
Indication and Important Safety Information
HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] Solution
  • HYQVIA is a liquid medicine containing immune globulin and Recombinant Human Hyaluronidase. HYQVIA contains IgG antibodies, collected from human plasma donated by healthy people. The antibodies help your body to fight off bacterial and viral infections. The hyaluronidase part of HYQVIA helps more of the immune globulin get absorbed into the body to fight infection.
  • HYQVIA is indicated for the treatment of Primary Immunodeficiency (PI) involving the humoral immune system in adults.
  • Safety and efficacy of chronic use of Recombinant Human Hyaluronidase in HYQVIA have not been established in conditions other than PI.
  • HYQVIA is infused under the skin (subcutaneous).
  • If you and your healthcare professional decide that home self-infusion of HYQVIA is right for you, then be sure you get instructions and training from your healthcare professional before using HYQVIA at home.
Important Safety Information
    • HYQVIA can cause blood clots.
    • Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
    • Your healthcare professional may perform blood tests regularly to check your IgG level.
    • With your consent, your healthcare professional may provide blood samples to Shire plc, to test for antibodies that may form against the hyaluronidase part of HYQVIA.
    • Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.
    • Talk to your healthcare professional if you become pregnant. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling Medical Information at 1-866-424-6724.

    Do not take HYQVIA if you:

    • Are allergic to IgG, hyaluronidase, other blood products, or human albumin (in the hyaluronidase solution).
    • Have IgA deficiency with antibodies to IgA.

    HYQVIA can cause serious side effects. Call your healthcare professional or go to your emergency department right away if you get:

    • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
    • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling in your brain.
    • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
    • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
    • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
    • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a lung problem.

    What are the possible or reasonably likely side effects of HYQVIA?

    • After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. Mild or moderate pain, redness, swelling, or itching may occur at the site of infusion and generally go away in a few hours. Local reactions are less likely after the first few infusions.
    • The most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.
    • Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long term effect. In theory, these antibodies could react with your body’s own PH20. PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects.

    These are not all the possible side effects with HYQVIA. Talk to your healthcare professional about any side effects that bother you or that don’t go away.

    Before starting HYQVIA, tell your healthcare professional if you:

    • Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
    • Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
    • Are pregnant, trying to become pregnant or are breast feeding.

    You are encouraged to report suspected side effects by contacting FDA at 1-800-FDA-1088 or www.fda.gov/medwatch or Shire Drug Safety at 1-800-999-1785.

    The risk information provided here is not comprehensive. To learn more, talk about HYQVIA with your healthcare provider or pharmacist.

    Please see the FDA-approved patient labeling