to a maintenance therapy with options

Personalized CIDP maintenance therapy

You’ve got options! HyQvia can provide different ways to get your treatment. You and your doctor can find the right combination to create an infusion experience that’s best for you.

HyQvia allows you to get your IG + Hy:

Every 2, 3, or 4
weeks as prescribed
by your doctor

Through 1-3
infusion sites*

In the abdomen
or the thighs

At home or in an
infusion center

With the support of a healthcare
provider, or through self-infusion
with the help of a care partner
after appropriate training

*If using three sites, the maximum is 400 mL per site.

Here are some things to keep in mind:

Don’t be surprised by the amount you infuse. It’s a large volume. Remember when we went over Hy? Well, Hy is what helps your body handle this larger volume: ~5 cups (1200 mL, or 600 mL for people weighing <40 kg [88 lbs]) is the most you’d infuse in a day. Thus, you’ll go through a ramp-up period to help you get used to this amount
It’s common to need more than one infusion site to receive your full dose. Most patients infuse using 2 sites, but because administration can be adapted to fit your needs, you might use only 1 site or could even use up to 3 sites. If you weigh 40 kg (88 lbs) or more, the maximum infusion volume is 600 mL per site (or as tolerated); if using three sites, the maximum is 400 mL per site
While many people are able to receive their full dose in one infusion, you may need to split your dose over more than one day

CIDP INFUSION OPTIONS

Multiple site of care options

HyQvia can be administered across multiple sites of care, including hospitals, infusion centers, offices, or at home with the support of a healthcare professional. Appropriate training is required prior to self-infusion.

In-center

HCP-supported administration might be the way to go if you:

Are not comfortable or unable to self-administer
Are apprehensive of or fear needles
Prefer infusions to be handled by a HCP
Lack the organizational skill, dexterity, or drive to reliably self-administer

At home

You might prefer self-infusion after appropriate training or HCP- or caregiver-supported administration if you:

Have logistical issues attending or live far away from an infusion center or a clinic
Need to fit infusions around work/home life
Want more independence with the option to self-infuse at home or an alternate location after appropriate training

PATIENT EXPERIENCE

Considering HyQvia?

Watch this video to find out if HyQvia might be an option for you.

STARTING INFUSIONS

Ramping up when starting treatment

There’s an adjustment period when starting HyQvia to help your body get used to treatment.

With HyQvia, you’ll go through something called a “ramp-up” period. What that means is you’ll start with a lower amount of HyQvia and slowly increase until you reach your full dose. There are different approaches to ramping up your dose—each approach takes multiple weeks. You’ll work closely with your doctor to choose the right ramp-up experience for you based on your dosing interval.

A ramp-up period doesn’t happen overnight

For example, you’ll start with infusing 25% of your monthly dose your doctor has prescribed and will slowly increase each time you infuse until you reach the full amount. Some weeks, you may skip an infusion and won’t receive any HyQvia at all.

The charts below are only examples of how your HyQvia dose may be ramped up. The percentages shown are based on the monthly calculated maintenance dose. Be sure to always take HyQvia as prescribed by your healthcare professional.

Dose ramp-up schedule if you will be receiving your maintenance dose every 2 weeks

X	25^%	25^%	50^%	X	X	X	X	X
1	2	3	4	5	6	7	8	9

Week Since Last IVIG Dose

X=No ramp-up infusion.

Dose ramp-up schedule if you will be receiving your maintenance dose every 3 weeks

X	25^%	25^%	50^%	X	75^%	X	X	X
1	2	3	4	5	6	7	8	9

Week Since Last IVIG Dose

X=No ramp-up infusion.

Dose ramp-up schedule if you will be receiving your maintenance dose every 4 weeks

X	25^%	25^%	50^%	X	75^%	X	X	100^%
1	2	3	4	5	6	7	8	9

Week Since Last IVIG Dose

X=No ramp-up infusion.

After the infusion

You may have a soft, wide swollen area around your infusion site due to the amount of fluid you infused. It’s called a “pancake,” and it’s normal! It means Hy worked and is helping the IG disperse in your fatty tissue. It should go away after 1-3 days.

Before infusion

Abdomen of a patient before a HyQvia infusion.

End of infusion

Abdomen of a patient at the end of a HyQvia infusion.

1-3 days after infusion

Abdomen of a patient 1-3 days after a HyQvia infusion.

Images are of a patient from a CIDP clinical trial who had 640 mL of HyQvia infused, divided into two sites.

Say Hy to Hy5 Video

See a nurse walk a patient through the infusion process in his own home.

5:38 Hy 1: Get Ready
6:54 Hy 2: Prepare the hyaluronidase, or Hy
11:37 Hy 3: Prepare the immune globulin or IG
16:44 Hy 4: Infuse
23:01 Hy 5: Finish Up

Find safety information here.

This is where you’ll find important safety info, including the warning about blood clots, to consider when starting and monitoring your treatment with HyQvia and to discuss with your doctor.

See safety info

UNDERSTANDING INSURANCE

Understanding the insurance process can make a difference

When you are prescribed a specialty medicine like HyQvia, your doctor may be required to reach out to your health plan to get preapproval for your treatment. Work with your doctor’s office to ensure you know what your insurance covers and how much HyQvia will cost.

Benefits verification

The first step in the process is for your doctor’s office to do a benefits verification on your behalf. They will work with your insurance company to determine if HyQvia is covered under your health plan, how much insurance will pay, what your deductible will be, and how much you will pay out of pocket. Once the office receives this information, speak to the office manager to fully understand what you are responsible for.

Prior authorization

Next, your doctor has to show your health plan that HyQvia is the appropriate treatment for you based on your medical profile. This is called prior authorization. Documentation and relevant lab tests will be sent to the health plan, and you must be approved before further coverage is granted.

Sometimes, these processes will be managed by a specialty pharmacy provider (SPP). Your SPP may contact you to coordinate these steps.

Working with your specialty pharmacy provider to get HyQvia

HyQvia is a specialty drug, which means you can’t pick up your prescription at the local pharmacy. SPPs carry drugs for rare conditions such as CIDP and make sure they are stored and handled appropriately before they are shipped. Your doctor will order HyQvia through an SPP, and it will be delivered to your preferred location.

Here’s what to expect when working with an SPP:

SPPs are able to support you by working directly with your insurance company to find out how your health plan covers HyQvia. They can assist with steps in the approval process, such as benefits verification, prior authorization, financial assistance, and treatment education—you can expect an SPP to contact you after a physician prescribes you HyQvia
SPPs will coordinate delivery of HyQvia. Depending on your discussion with your doctor, you will have HyQvia delivered to your home or to an infusion center. They may also give you special instructions on how to store your drug properly before you take it
Some insurance companies may only work with certain specialty pharmacies. Currently, only the below SPPs have HyQvia in stock. Work with your doctor’s office or an insurance representative to determine which SPP is available to you

The following SPPs are currently authorized to dispense HyQvia:

AcariaHealth

Accredo (incl. Cigna Tel-Drug)

AIS

AllianceRx Walgreens Prime

BioMatrix

BriovaRx

CVS Specialty

Diplomat

Humana RightSource

InfuCare Rx

KabaFusion

Kroger

Nufactor

Option Care (incl. BioScrip)

Oso

Soleo

Superior Biologics

US Bioservices

Ready to talk to your doctor?

Great. We’ve got just the thing for you. Our Doctor Discussion Guide can help you get organized and ready for your conversation with your doctor.

Go to the guide

CIDP=chronic inflammatory demyelinating polyneuropathy; HCP=healthcare professional; Hy=hyaluronidase; IG=immune globulin; IVIG=intravenous immune globulin.

IMPORTANT SAFETY INFORMATION and serious warnings regarding blood clots

What is HYQVIA?

HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat chronic inflammatory demyelinating polyneuropathy (CIDP) in adults.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about HYQVIA?

HYQVIA can cause blood clots.
Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
Your HCP may perform blood tests regularly to check your IgG level.
Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.

Who should not take HYQVIA?

Do not take HYQVIA if you:

Are allergic to IgG, hyaluronidase, other blood products, or any ingredient in HYQVIA.

What should I avoid while taking HYQVIA?

HYQVIA can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your HCP that you take HYQVIA.

What should I tell my HCP before I start using or while using HYQVIA?

Tell your HCP if you:

Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
Are pregnant, trying to become pregnant or are breast feeding. It is not known whether HYQVIA can harm the unborn baby or breastfed infant.

What are the possible or reasonably likely side effects of HYQVIA?

HYQVIA can cause serious side effects. If any of the following problems occur after starting HYQVIA, stop the infusion immediately and contact your HCP or call emergency services:

Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
Fever over 100°F. This could be a sign of an infection.

After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. The following possible side effects may occur at the site of infusion and generally go away within a few hours, and are less likely after the first few infusions.

Mild or moderate pain
Redness
Swelling
Itching

The most common side effects of HYQVIA are:

Headache
Fatigue
Nausea
Fever
Itching
Redness
Abdominal pain
Back pain
Pain in extremity

Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long-term effect. In theory, these antibodies could react with your body’s own hyaluronidase (PH20). PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side-effects.

These are not all the possible side effects. Talk to your HCP about any side effect that bothers you or that does not go away.

For additional safety information, click for Information For Patients and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

What is HYQVIA?

HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat chronic inflammatory demyelinating polyneuropathy (CIDP) in adults.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about HYQVIA?

HYQVIA can cause blood clots.
Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
Your HCP may perform blood tests regularly to check your IgG level.
Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.

Who should not take HYQVIA?

Do not take HYQVIA if you:

Are allergic to IgG, hyaluronidase, other blood products, or any ingredient in HYQVIA.

What should I avoid while taking HYQVIA?

HYQVIA can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your HCP that you take HYQVIA.

What should I tell my HCP before I start using or while using HYQVIA?

Tell your HCP if you:

Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
Are pregnant, trying to become pregnant or are breast feeding. It is not known whether HYQVIA can harm the unborn baby or breastfed infant.

What are the possible or reasonably likely side effects of HYQVIA?

HYQVIA can cause serious side effects. If any of the following problems occur after starting HYQVIA, stop the infusion immediately and contact your HCP or call emergency services:

Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
Fever over 100°F. This could be a sign of an infection.

Mild or moderate pain
Redness
Swelling
Itching

The most common side effects of HYQVIA are:

Headache
Fatigue
Nausea
Fever
Itching
Redness
Abdominal pain
Back pain
Pain in extremity

These are not all the possible side effects. Talk to your HCP about any side effect that bothers you or that does not go away.

For additional safety information, click for Information For Patients and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

©2024 Takeda Pharmaceuticals U.S.A., Inc., 300 Shire Way, Lexington, MA 02421. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA^®, the TAKEDA Logo^®, and the TAKEDA Patient Support Logo™ are trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. HYQVIA^® and MYIGSOURCE™ are trademarks or registered trademarks of Baxalta Incorporated.
US-HYQ-0946v1.0 04/24