Do you know about subQ?

HyQvia is infused subcutaneously, or the subQ way.

That means it’s given just under your skin, not into a vein.

There are two different ways to infuse HyQvia subcutaneously. You can infuse with a peristaltic pump, or you can infuse with a syringe driver pump. You’ll talk with your doctor about the best way for you to infuse, and the specialty pharmacy and nurse who trains you can talk you through any specific questions you may have, including questions about the pump you’ll be using.

When starting to infuse, there’s a ramp-up period.

This means that you’ll start slowly and gradually build up to your prescribed dose since it’s new to your body. Your ramp-up schedule will be given to you by your doctor and will, over time, get you to your full prescribed dose. You’ll eventually shift from 1 infusion a week to 1 infusion every 3 or 4 weeks, depending on the frequency your doctor prescribes. Your doctor will decide if any dose adjustments need to be made, as necessary, based on your clinical response.

Ramp-up example for 30-gram dose of HyQvia with a 4-week treatment interval*

The first dose of HyQvia is given 1 week after the last infusion of the patient’s previous IG treatment.

Here’s how an infusion site typically looks before and after infusing.

Knowing what to expect will hopefully make starting your infusions less stressful. Everyone’s infusion experience is different. However, it’s not uncommon to experience a temporary, soft swelling at the infusion site. You may hear someone refer to this as a “pancake” because that’s what it looks like. It happens because of the volume of fluid infused and may last anywhere from 1 to 3 days after your infusion. For some, it’s gone the next day.

Beginning of infusion

Abdomen of patient at the beginning of a HyQvia infusion.

Patient weight: 168 lb Volume: 500 mL

End of infusion

Abdomen of patient at the end of a HyQvia infusion.

Results in diffuse, pancake-like swelling

24 hours after infusion

Abdomen of patient 24 hours after a HyQvia infusion.

Infusion site swelling generally resolved within 1 to 3 days

What the infusion experience is like.

Before the infusion:

Get comfy
Get your supplies out and ready
Read over the infusion steps if you need to, especially if you're just starting out
If appropriate, make sure you're hydrated before infusing and have a drink nearby in case you're thirsty during your infusion
If others are around, let them know your infusion time so there's as little disruption for you as possible
Always follow the directions provided by your doctor regarding your dose and schedule

During the infusion:

Try your best to relax and stay comfy, as the average infusion time is about 2 hours. Read, play a game, catch up on your fave show, call a friend, get creative and use this time for you
You may experience mild to moderate pain, redness, swelling and itching (BUT, these are common and generally go away within a few hours). These aren't all of the possible side effects, but ones you may immediately notice
In addition to local infusion site reactions, the most common side effects may include headache, nausea, fatigue, diarrhea, fever, and vomiting
These are not all the possible side effects. Talk to your doctor about any side effect that bothers you or that does not go away. If side effects increase in severity or persist more than a few days, call your doctor or hospital emergency services immediately

After the infusion:

If appropriate, continue to drink fluids to stay hydrated
Record your infusion details and any reactions or notes for yourself or your doctor. Make sure to inform your doctor about any side effect that bothers you or does not go away
A temporary, soft swelling, referred to as a pancake (yep, a pancake), may occur at your infusion site. It's named for the shape it takes and is pretty common. It can last 1 to 3 days due to the volume of fluid infused but will subside as your medicine is absorbed

Find safety information here.

This is where you’ll find important safety info, including the warning about blood clots, to consider when starting and monitoring your treatment with HyQvia.

See safety info

INFUSING WITH PERISTALTIC PUMP

Peristaltic pumps

This pump helps deliver your prescribed dose, at an infusion rate you and your doctor are comfortable with.

Want to see for yourself? Watch the video. Would you rather read more? Get the brochure.

0:00 Get familiar with hy5
3:35 hy1: Get ready
4:31 hy2: Prepare the hyaluronidase, or Hy
6:42 hy3: Prepare the immune globulin, or IG
10:37 hy4: Infuse
15:30 hy5: Finish up

INFUSING WITH SYRINGE DRIVER PUMP

Syringe Driver Pump

Download the brochure to learn more.

Download brochure

Thumbnail PDF of how to Infuse HyQvia With a Syringe Driver Pump guide.

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IMPORTANT SAFETY INFORMATION and serious warnings regarding blood clots

What is HYQVIA?

HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat primary immunodeficiency (PI) in people 2 years and older.

IMPORTANT SAFETY INFORMATION

What is the most important information that I should know about HYQVIA?

HYQVIA can cause blood clots.
Call your healthcare professional (HCP) if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body.
Your HCP may perform blood tests regularly to check your IgG level.
Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread.

Who should not take HYQVIA?

Do not take HYQVIA if you:

Are allergic to IgG, hyaluronidase, other blood products, or any ingredient in HYQVIA.

What should I avoid while taking HYQVIA?

HYQVIA can make vaccines (like measles/mumps/rubella or chickenpox vaccines) not work as well for you. Before you get any vaccines, tell your HCP that you take HYQVIA.

What should I tell my HCP before I start using or while using HYQVIA?

Tell your HCP if you:

Have or had any kidney, liver, or heart problems or history of blood clots because HYQVIA can make these problems worse.
Have IgA deficiency or a history of severe allergic reactions to IgG or other blood products.
Are pregnant, trying to become pregnant or are breast feeding. It is not known whether HYQVIA can harm the unborn baby or breastfed infant.

What are the possible or reasonably likely side effects of HYQVIA?

HYQVIA can cause serious side effects. If any of the following problems occur after starting HYQVIA, stop the infusion immediately and contact your HCP or call emergency services:

Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain.
Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem.
Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot.
Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem.
Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.
Fever over 100°F. This could be a sign of an infection.

After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. The following possible side effects may occur at the site of infusion and generally go away within a few hours, and are less likely after the first few infusions.

Mild or moderate pain
Redness
Swelling
Itching

The most common side effects of HYQVIA are:

Headache
Fatigue
Nausea
Fever
Vomiting

Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long-term effect. In theory, these antibodies could react with your body’s own hyaluronidase (PH20). PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side-effects.

These are not all the possible side effects. Talk to your HCP about any side effect that bothers you or that does not go away.

For additional safety information, click for Information For Patients and discuss with your HCP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.