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Old blue-capped and updated purple-capped HyQvia vials and casing. Old blue-capped and updated purple-capped HyQvia vials and casing.

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HyQvia [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] can be infused every 3 to 4 weeks in the stomach or thighs, in 1 or 2 infusion sites, at home or in your physician’s office. Talk to your doctor about what’s best for you.

If you’re new to HyQvia, this section is for you.

Lean on your healthcare team. They’re there to support you and help you learn, and that’s so important so you feel prepared for the process of before, during, and after infusing HyQvia. The Detailed Instructions for Infusion Administration included in the Information for Patients is also a useful resource.

Clip art of a hand holding a HyQvia Ig bottle.

Before the infusion

Do not use HyQvia at home until you get instructions and training from your healthcare professional.

  • Always follow the directions provided to you by your healthcare provider regarding the dose, schedule, and how to infuse HyQvia
  • Choose a less busy day and plan ahead to avoid disruptions while you’re infusing
  • Set up your supplies in a clean area and carefully read the instructions provided to you
  • Allow HyQvia to reach room temperature (this may take up to 60 minutes). Do not apply heat or place in microwave
  • You can store HyQvia in the refrigerator (36° to 46°F [2° to 8°C]) for up to 36 months. Do not freeze
  • HyQvia can be stored at room temperature (up to 77°F [25°C]) for up to 3 months, during the first 24 months from the date of manufacturing printed on the carton. Do not return HyQvia to the refrigerator if you take it out to room temperature
  • When storing HyQvia, be sure to keep it in the box to protect it from light
Clip art showing how to infuse HyQvia.

During the infusion

  • Get comfortable and try to relax
  • Local infusion-site reactions such as mild to moderate pain, temporary soft pancake-like swelling, itching, and skin redness are common with HyQvia
    • Swelling may last 1 to 3 days, due to the volume of fluid infused
    • Other infusion-site reactions generally go away within a few hours
    • Local reactions are less likely after the first few infusions
  • In addition to local reactions, most common side effects may include headache, fatigue, nausea, fever, and vomiting
  • If side effects increase in severity or persist for more than a few days, call your physician or hospital emergency services immediately
  • Never infuse HyQvia into or around an infected or red swollen area
  • Let your doctor know if you experience any leakage at your infusion site

If any of the following problems occur after starting HyQvia, stop the infusion immediately and contact your healthcare provider or call emergency services:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting, or dizziness. These could be signs of a serious allergic reaction
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of irritation and swelling of the lining around your brain
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem
  • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem
  • Fever over 100°F. This could be a sign of an infection

These are not all of the possible side effects for HyQvia. Talk to your healthcare professional about any side effects that bother you or that don’t go away.

Clip art of a hand with a pen recording HyQvia infusion time on a notebook.

After the infusion

  • Record your infusion time, date, dose, infusion-site location, and any reactions you may experience in your infusion log
  • Make sure to follow up with your physician routinely

Familiar with your HyQvia supplies?

How about what to do with them? From what your supplies are to your administration process, these helpful resources walk you through it all.

How to infuse HyQvia with a Peristaltic Infusion pump

How to Infuse HyQvia With a Syringe Driver Pump

Thumbnail PDF of how to Infuse HyQvia With a Syringe Driver Pump guide. Download PDF

Detailed Instructions for Administration

Thumbnail PDF of detailed Instructions for Administration guide. Download PDF

How to Infuse HyQvia With a Peristaltic Infusion Pump

Thumbnail PDF of HyQvia infusion cheat sheet. Download PDF
Purple arrow on a window application icon depicting how to get more information about HyQvia.

There are helpful resources

There are helpful resources

Whether you’re looking for info about supplies or the infusion process, it’s all here.

Get Resources
Mary and Michael: patients on HyQvia.

Know what to expect

Know what to expect

Watching others infuse will help you better understand the process.

See Mary & Michael