HYQVIA is a liquid medicine that is given under the skin (subcutaneously) to treat primary immunodeficiency (PI) in adults.

What to expect

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What to Expect with HYQVIA | Subcutaneous Immunoglobulin Infusion

See Real Patient Experiences with HyQvia Infusion.

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Initial treatment and ramp-up schedule

Your healthcare provider will use a ramp-up schedule for starting HyQvia. To help you become comfortable with your treatment, you will receive the first dose of HyQvia and will ramp-up gradually. Your dose will eventually shift from 1 time a week to 1 time every 3 or 4 weeks, depending on the frequency your doctor prescribed for you. Dose adjustment of HyQvia may be necessary based on your clinical response. See the chart below for an example of a ramp-up schedule for every 4 week dosing.

Ramping-up at a glance

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] infusions schedule

Flexible administration.

HyQvia can be infused every 3 or 4 weeks in either the stomach or thighs. Following your infusion with HyQvia, it’s not uncommon to experience a temporary, soft swelling at the infusion site. This is due to the volume of fluid infused and may last 1 to 3 days after your infusion.

500 mL Infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site prior to 500 mL infusion

Pre-infusion
Patient weight: 168 lbs

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of post-infusion swelling with 500 mL infusion

End of infusion
Results in diffuse, pancake-like swelling

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site 24 hours after 500 mL infusion

24 hours after infusion
Infusion site swelling generally resolved within 1 to 3 days

Beginning
of infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site prior to 500 mL infusion

Patient weight: 168 lbs Volume: 500 mL

End of
infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of post-infusion swelling with 500 mL infusion

Results in diffuse, pancake-like swelling

24 hours after
infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site 24 hours after 500 mL infusion

Infusion site swelling generally resolved within 1 to 3 days

300 mL Infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site prior to 300 mL infusion

Pre-infusion
Patient weight: 162 lbs

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of a mild local site reaction during infusion.

Infusion
Results in minor local swelling

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of post-infusion tenderness with 300 mL infusion

Post-infusion
Side effects include acute tenderness

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site 24 hours after 300 mL infusion

24 hours after infusion
Infusion site swelling generally resolved within 1 to 3 days

Pre-Infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site prior to 300 mL infusion

Patient weight: 162 lbs Volume: 300 mL

Infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of a mild local site reaction during infusion.

Results in minor local swelling

Post-Infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of post-infusion tenderness with 300 mL infusion

Side effects include acute tenderness

24 hours after
infusion

HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] patient example of infusion site 24 hours after 300 mL infusion

Infusion site swelling generally resolved within 1 to 3 days

  • In the clinical trials, there were no observable changes in the skin or subcutaneous tissue in almost 3,000 infusions and maximum exposure over 3 years*
  • To help you become comfortable with your treatment, you will receive the first dose of HyQvia and will ramp up gradually. Your dose will eventually shift from 1 time a week to 1 time a month
  • Do not attempt to self-administer HyQvia until you have been trained by a healthcare provider

*2,959 infusions and ~3.5 subject-years.

Every 3 or 4 weeks.

Side effects and Important Information. Front and center.

In addition to local side effects, the most common systemic side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting.

HyQvia can cause serious side effects. If any of the following problems occur after starting HyQvia, stop the infusion immediately and contact your healthcare provider or call emergency services:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting, or dizziness. These could be signs of a serious allergic reaction
  • Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling and irritation of the lining around your brain
  • Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem
  • Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem
  • Fever over 100°F. This could be a sign of an infection

Talk to your healthcare professional about any side effects that bother you or that don’t go away